The German and American doctors suggested that Liu be sent abroad and receive treatment, but the Chinese doctors said there are risks transferring the patient and asked if the overseas experts had better plans. The dispute is likely to increase concerns about his plight.
In 2010, while in prison, Liu was awarded the Nobel Peace Prize for "his long and nonviolent struggle for fundamental human rights in China" - prompting an infuriated Beijing to place his wife under house arrest and freeze diplomatic ties with Norway, where the prize victor is chosen.
The hospital said the experts were Dr Markus W Buchler, of Heidelberg University in Germany, and Dr Joseph Herman, of the MD Anderson Cancer Centre in Texas.
Herman and Büchler visited Liu on Saturday afternoon.
Citing Liu Hui, Zeng said the inhibitor drug, Sorafenib, has failed to work on Liu Xiaobo.
The First Hospital of China Medical University in the northeastern city of Shenyang said in a statement that the lead doctor had informed Liu's family of the development.
But they said that Liu expressed a desire to leave China, and that they judged that he "can be safely transported with appropriate medical evacuation care and support".
"We have no better method" of treating Mr Liu, it quoted the global experts as saying in response to a question about whether the laureate would receive more effective treatment overseas.
"The patient is suffering from advanced liver cancer that has metastasised to his entire body and is at the end stage", the hospital said.
Photographs posted on the hospital's website showed the two experts examining Mr Liu, who is in a hospital bed and appears emaciated and weak.
Opioid Prescriptions Fall, But Still High: CDC
Since the new report covered data from 2006 to 2015, developments from these new recommendations had not been captured. Daily MME per prescription remained stable from 2006 to 2010 and then decreased 17% from 2010 to 2015.
If his liver function improves, they could consider immunotherapy, but for now Liu will continue supportive therapy to alleviate the pain and "elevate his quality of life", the hospital said.
He became only the third person to receive a Nobel Peace award while being imprisoned by his own government in 2010. At times, Liu was lucid enough to communicate in English, Shang said.
Meanwhile, Hong Kong-based FactWire News Agency reported on Sunday that in a previously unreleased interview in February 2009, Liu's wife Liu Xia said Liu Xiaobo had not thought he would be arrested for drafting Charter 08, a manifesto calling for political reforms in China.
Hu Jia, a Chinese dissident and family friend, said that Beijing is afraid of letting its most potent opposition symbol go overseas as long as he is able to speak to the media.
Mr. Shang said he was not sure why Mr. Liu preferred Germany, but that seemed to be the first preference of his wife, Liu Xia, who is under house arrest.
Liu's two brothers, who were traveling from their homes in southern and northeastern China, were being closely monitored by state security agents along the way - making it hard to maintain contact with them, Hu said.
China's foreign ministry had no immediate response to a request for comment Saturday.
"Liu Xiaobo is one step closer to freedom".
The United Nations human rights office demanded last Friday (July 7) that the UN be given access to Mr Liu, but as world leaders met with their Chinese counterpart in Germany, they remained largely silent on laureate's fate.